Clinical Research Directory

Inclusion Criteria: 1. Experienced an ischemic or hemorrhagic stroke that resulted in arm and hand hemiparesis more than 6 months prior to the time of enrollment (Prior strokes that did not cause upper extremity motor deficits are not exclusionary.) 2. Age 22 to 70 years old 3. Upper extremity motor score higher than 20 and lower than or equal to 45 on the Fugl-Meyer Assessment (FMA) scale 4. FMA upper extremity sensory score higher than 6 points (out of 12 points) 5. The ability to communicate, understand, give appropriate consent and follow two-step commands Exclusion Criteria: 1. Presence of any serious disease or disorder (ex. Neurological conditions other than stroke, cancer, severe cardiac or respiratory disease, renal failure, etc.) that could affect their ability to participate in this study 2. Considered to be at high-risk of recurrent stroke as evident from their medical history or upon judgment of the study physician 3. Presence of post-stroke central pain, other forms of pain or other constraints such as joint contractures in the paretic arm that are serious enough to prevent or affect the correct execution of the physical training protocol as judged by the study therapist 4. A score on the Short Blessed Test assessment scale lower than 9 5. Female participants of child-bearing age who are pregnant or breastfeeding during the study 6. Participants that cannot suspend their antiplatelets and/or anticoagulant therapy for two weeks around the time of surgery 7. Existence of any implanted medical device that is not MRI safe and/or any active medical devices even if it is MRI safe 8. Implanted spinal fusion and stabilization devices such as plates and rods between the C2 and T3 spinal vertebra 9. Obstructed or restricted epidural spinal canal to the point of hindering or increasing the risk of implant of the spinal leads as judged by the study surgeon upon screening imaging 10. Severe claustrophobia that prevents execution of the required MRI imaging sessions 11. Taking anti-spasticity or anti-epileptic medications 12. T-score higher than 63 on the 18-question Brief Symptoms Inventory (BSI-18) who have undergone discussions with and been deemed unsuitable by the Principal Investigator and a study physician Potential participants who may be excluded on initial screening may discuss possible medication changes with their physician.