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A Study of IL4Rα Monoclonal Antibody in Patients With Seasonal Allergic Rhinitis
Sponsor: Genrix (Shanghai) Biopharmaceutical Co., Ltd.
Summary
Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by immunoglobulin E after exposure to allergens in atopic individuals. The typical symptoms of AR are paroxysmal sneezing, watery rhinorrhea, itching, and nasal congestion, which may be accompanied by ocular symptoms, including eye itching, tearing, redness, and burning sensation, which are more common in patients with hay fever allergies.
Official title: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase III Clinical Trial to Evaluate the Efficacy and Safety of GR1802 Injection in Combination With Background Therapy in Patients With SAR
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2025-08-15
Completion Date
2026-07-31
Last Updated
2025-09-04
Healthy Volunteers
No
Conditions
Interventions
GR1802 injection
Recombinant fully human anti-IL4Rα monoclonal antibody drug.
Placebo
Placebo
Locations (1)
Zhongnan Hospital of Wuhan university
Wuhan, Hubei, China