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Day-3 vs Day-5 Assisted Hatching: Impact on Blastocyst Morphology and PGT-A Outcomes
Sponsor: Hoang Minh Ngan
Summary
This randomized controlled trial compared assisted hatching (AH) performed on Day 3 versus Day 5 in patients undergoing IVF-ICSI with preimplantation genetic testing for aneuploidy (PGT-A). Eligible participants were randomly assigned to one of the two AH strategies, and all embryos from each IVF-ICSI cycle followed the assigned strategy. The study evaluated whether the timing of AH was associated with differences in blastocyst development, blastocyst morphology, and PGT-A outcomes. The findings are intended to help optimize the timing of assisted hatching in IVF laboratory practice.
Official title: Randomized Controlled Trial of Assisted Hatching Timing (Day-3 vs Day-5) and Its Impact on Blastocyst Morphology and Genetic Outcomes in IVF Cycles Undergoing PGT-A
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
158
Start Date
2025-06-14
Completion Date
2026-07-07
Last Updated
2026-08-18
Healthy Volunteers
No
Interventions
Laser-Assisted Hatching
A standardized laser-assisted opening of the zona pellucida was performed either on Day 3 or Day 5 according to randomized group assignment. The only protocol-defined difference between study arms was the timing of assisted hatching; subsequent blastocyst culture, Day-5 assessment, and trophectoderm biopsy procedures were standardized across both groups.
Locations (1)
Center for Reproductive Support, 16A Ha Dong General Hospital
Hanoi, Hanoi, Vietnam