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Day-3 vs Day-5 Assisted Hatching: Impact on Blastocyst Morphology and PGT-A Outcomes
Sponsor: Hoang Minh Ngan
Summary
This randomized controlled trial compared assisted hatching (AH) performed on Day 3 versus Day 5 in patients undergoing IVF-ICSI with preimplantation genetic testing for aneuploidy (PGT-A). Eligible IVF-ICSI cycles were randomly assigned to one of the two AH strategies, and all embryos from each randomized cycle followed the assigned strategy. The study evaluated whether the timing of AH was associated with differences in blastocyst development, blastocyst morphology, and PGT-A outcomes. The findings are intended to help optimize the timing of assisted hatching in IVF laboratory practice.
Official title: Randomized Controlled Trial of Assisted Hatching Timing (Day-3 vs Day-5) and Its Impact on Blastocyst Morphology and Genetic Outcomes in IVF Cycles Undergoing PGT-A
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
141
Start Date
2025-06-14
Completion Date
2026-07-07
Last Updated
2026-09-10
Healthy Volunteers
No
Interventions
Laser-Assisted Hatching
A standardized laser-assisted opening of the zona pellucida was performed either on Day 3 or Day 5 according to randomized group assignment. The only protocol-defined difference between study arms was the timing of assisted hatching; subsequent blastocyst culture, Day-5 assessment, and trophectoderm biopsy procedures were standardized across both groups.
Locations (1)
Center for Reproductive Support, 16A Ha Dong General Hospital
Hanoi, Hanoi, Vietnam