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NOT YET RECRUITING
NCT07155694
PHASE4

Role of Finerenone in African American Veterans With Diabetic Kidney Disease

Sponsor: Washington D.C. Veterans Affairs Medical Center

View on ClinicalTrials.gov

Summary

Primary Objectives: To study podocyte specific injury markers (podocyte specific proteins, PSP) nephrin, podocalyxin and Wilms'Tumor (WT-1) protein in exosomes urine from African American Veterans with albuminuric stage 2 and 3 chronic diabetic kidney disease (DKD), using Empagliflozin or Finerenone or combination therapy. Secondary Objectives: (1). Correlate changes in exosome-based PSP with standardized biomarkers of kidney injury including urine albumin/creatinine ratio (ACR) and estimated GFR. (2) with systemic inflammatory markers (focusing on vascular and endothelial function) that are already established such as interleukins (IL1, IL6, IL-12), hs-CRP and (3) arterial stiffness measures and with (4) APOL1 mRNA expression levels in peripheral blood derived mononuclear cells (MNC).

Key Details

Gender

All

Age Range

20 Years - 90 Years

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2025-09

Completion Date

2027-08

Last Updated

2025-09-04

Healthy Volunteers

No

Interventions

DRUG

Finerenone 10 MG

Take Finerenone 10 mg orally daily

DRUG

Empagliflozin 10 MG

Take Empagliflozin 10 mg orally daily for 4 months

Locations (1)

Washington DC Veterans Affairs Medical Center (688)

Washington D.C., District of Columbia, United States