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Role of Finerenone in African American Veterans With Diabetic Kidney Disease
Sponsor: Washington D.C. Veterans Affairs Medical Center
Summary
Primary Objectives: To study podocyte specific injury markers (podocyte specific proteins, PSP) nephrin, podocalyxin and Wilms'Tumor (WT-1) protein in exosomes urine from African American Veterans with albuminuric stage 2 and 3 chronic diabetic kidney disease (DKD), using Empagliflozin or Finerenone or combination therapy. Secondary Objectives: (1). Correlate changes in exosome-based PSP with standardized biomarkers of kidney injury including urine albumin/creatinine ratio (ACR) and estimated GFR. (2) with systemic inflammatory markers (focusing on vascular and endothelial function) that are already established such as interleukins (IL1, IL6, IL-12), hs-CRP and (3) arterial stiffness measures and with (4) APOL1 mRNA expression levels in peripheral blood derived mononuclear cells (MNC).
Key Details
Gender
All
Age Range
20 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-09
Completion Date
2027-08
Last Updated
2025-09-04
Healthy Volunteers
No
Conditions
Interventions
Finerenone 10 MG
Take Finerenone 10 mg orally daily
Empagliflozin 10 MG
Take Empagliflozin 10 mg orally daily for 4 months
Locations (1)
Washington DC Veterans Affairs Medical Center (688)
Washington D.C., District of Columbia, United States