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Long-term Outcomes of Prostate Cancer Screening
Sponsor: Karolinska Institutet
Summary
This study is an expansion of the screening-by-invitation STHLM3MRI trial for detection of prostate cancer. In summary, we assess longterm outcomes (prostate cancer mortality, incidence and resource use) in men (i) invited and randomized to a screening program using PSA, a biomarker test and MRI; (ii) invited and randomized to a single PSA test with prostate biopsies followed by opportunistic testing and (iii) population controls. Mortality is verified through register data, disease verification is made through in-study biopsy results and registry data.
Official title: Long-term Outcomes of Prostate Cancer Screening Using PSA, Biomarkers and MRI: The STHLM3MRI Trial
Key Details
Gender
MALE
Age Range
50 Years - 74 Years
Study Type
INTERVENTIONAL
Enrollment
7500
Start Date
2024-11-01
Completion Date
2035-11
Last Updated
2025-09-04
Healthy Volunteers
Yes
Conditions
Interventions
PSA/Stockholm3/MRI
Stockholm3+PSA followed by MRI of the prostate
PSA
PSA followed by standard biopsies
Locations (1)
Karolinska Institutet
Stockholm, Sweden