Clinical Research Directory

Inclusion Criteria: * BMI 22-30 kg/m² * Inactive (\<150 minutes of moderate to vigorous physical activity per week and no regular resistance training), * Covered by a social security system * Agrees to undergo the study interventions (undirect calorimetry, functional tests, physical activity program) Exclusion Criteria: * Hamilton HAD scale with a score \> 9 * Subject with a pathology or treatment (diabetic on insulin, corticosteroids \> 8 days, neuroleptics, anticoagulant, antiplatelet) judged by the investigator as incompatible with the study * Subject with unstabilized thyroid dysfunction for at least 3 months * Subject with unstabilized hypertension for at least 3 months * Subject with a medical and/or surgical history judged by the investigator as incompatible with the trial * More than 21 alcoholic drinks per week * Heavy smoker (\>10 cigarettes/day) * Currently participating in another intervention study * Absence of informed consent * Inability to participate in physical activity * Allergy(ies) or refusal to consume one of the foods tested as part of the the study * Allergy to local anesthetics * Declared glaucoma * Prostate hypertrophy * Refusal to register in the national file of volunteers who participate in research involving human beings * Subject in a period of exclusion from a previous study or having received a total amount of compensation greater than 6,000 euros over the 12 months preceding the start of the trial (after verification in the File of Volunteers for Research involving Human Beings) * Patients under guardianship, curatorship, deprived of liberty or legal protection * Subject with claustrophobia