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NCT07156617

A Study on the Heterogeneity of Efficacy of Interventional Therapy Combined With Systemic Therapy for Liver Cancer Based on Multi-center Real-world Data

Sponsor: Xuhua Duan

View on ClinicalTrials.gov

Summary

The system assesses the heterogeneity of HCC patients in terms of therapeutic outcomes (such as rwPFS, ORR, PRO) and adverse reactions during the process of interventional therapy combined with systemic treatment. It explores the clinical characteristics and biomarker levels of patients related to heterogeneity and builds a machine learning model to predict the risk of adverse reactions, providing evidence support for the construction of a patient-centered individualized decision-making system.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

2000

Start Date

2025-10-01

Completion Date

2028-10-01

Last Updated

2025-09-05

Healthy Volunteers

No

Interventions

PROCEDURE

Interventional therapy

Interventional therapy

DRUG

Systemic therapy

Targeted Therapy drugs include but are not limited to Lenvatinib, Apatinib, etc. Immunotherapy drugs include but are not limited to Camrelizumab, Tislelizumab

Locations (14)

The Second Affiliated Hospital of Hainan Medical Universsity

Haikou, Hainan, China

Xingtai No.5 Hospital

Xingtai, Hebei, China

Deng zhou People's Hospital

Dengzhou, Henan, China

The Second People's Hospital of Jiaozuo

Jiaozuo, Henan, China

Huai He Hospital of Henan University

Kaifeng, Henan, China

Luo Yang Central Hospital

Luoyang, Henan, China

The First Affiliated Hospital of Henan University of science and Technology

Luoyang, Henan, China

First People's Hospital of Shangqiu

Shangqiu, Henan, China

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China

Zhou Kou Central Hospital

Zhoukou, Henan, China

Wuxi No.5 People's Hospital

Wuxi, Jiangsu, China

Jiangxi Provincial People's Hospitail

Nanchang, Jiangxi, China

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

Second People's Hospital of Jiaozuo

Jiaozuo, China