Clinical Research Directory

Inclusion Criteria: * Patient undergoing ACL repair or ACL reconstruction with tendon autograft * Age 13-50 years old * Able to provide informed consent or parent/legal guardian is able for minors Exclusion Criteria: * Concurrent and significant injury to other bones or organs (Injury Severity Score of 4 or greater) * Revision ACL reconstruction * Concomitant additional ligament reconstruction or high tibial osteotomy * A history of alcohol abuse, substance abuse or chronic opioid use (filled opioid medication ×2 within 6 months of the surgery) * A history of renal failure (\<60 mL/min/1.73 m2), liver dysfunction (child class, \>B), severe heart disease (NYHA Class 4), diabetes, neurological or psychiatric diseases that may affect pain perception, and pre-existing immune suppression. * A history or active peptic ulcer disease, gastrointestinal bleeding, or current use of anticoagulation. * Patients currently taking oral or injectable glucocorticoids and those who have taken either within 1 month of the procedure. * Patients who are currently pregnant. * Patients who are unable to undergo the multimodal pain standardized protocol including those with comorbidities or medical allergies precluding the use of corticosteroids, gabapentin, hydrocodone, acetaminophen, ketorolac, and/or meloxicam.