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Study of Protection And Repair of Endothelial-glycocalyx in Sepsis
Sponsor: Beth Israel Deaconess Medical Center
Summary
Sepsis damages the blood vessel lining and its protective "glycocalyx," contributing to organ failure and death. This pilot, randomized, blinded study will test whether giving fresh frozen plasma (FFP)-either as intermittent boluses or as a continuous infusion-protects or repairs the glycocalyx compared with look-alike placebo fluid (lactated Ringer's with multivitamins), and whether this leads to better clinical outcomes. We will measure blood and urine biomarkers of glycocalyx injury and track organ support needs, ICU/hospital-free days, and survival through 28-90 days.
Official title: Pilot Study of Protection And Repair of Endothelial-glycocalyx in Sepsis (SPARES)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2025-11-01
Completion Date
2027-10-01
Last Updated
2025-09-08
Healthy Volunteers
No
Conditions
Interventions
Fresh Frozen Plasma (blood product)
Fresh Frozen Plasma
MVI and lactated ringers
placebo