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Physical Exercise to Prevent Mild-cognitive Impairment in Patients With Kidney Disfunctions
Sponsor: Biogem s.c.ar.l.
Summary
This research project focuses on improving memory and thinking (cognitive function) in people with advanced chronic kidney disease (CKD), a condition that affects about 10% of adults and is often linked to cognitive problems. The study includes a clinical trial where patients will either receive standard care or follow a home-based exercise program involving walking and strength training, to see if regular physical activity can improve brain function. It also includes a large-scale analysis of data from the UK Biobank to explore blood and genetic markers, brain imaging, and lifestyle factors linked to cognitive health. The ultimate aim is to find effective, easy-to-implement strategies and early warning signs that could lead to better treatment and quality of life for people living with CKD.
Official title: Physical Exercise to Prevent Mild-cognitive Impairment Progression in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
124
Start Date
2026-01-01
Completion Date
2030-04-30
Last Updated
2025-09-08
Healthy Volunteers
No
Interventions
Exercise
Patients will undergo a home-based low-intensity interval multi component exercise program including aerobic and strengthening exercise
Control (Standard treatment)
Patients will be treated with standard therapy based on their CKD stage
Locations (6)
Assistance Publique - Hôpitaux de Paris (AP-HP), Division of Geriatry
Paris, France
Biogem
Ariano Irpino, Italy
Lithuanian University of Health Sciences
Kaunas, Lithuania
University Medical Center Groningen, Department of Nephrology
Groningen, Netherlands
Medical University of Warsaw, Department of Nephrology, Dialysis and Internal Medicine
Warsaw, Poland
University of Zurich
Zurich, Switzerland