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Comparing the Efficacy and Safety of Different Postoperative Adjuvant Regimens in Patients With Resectable Adenocarcinoma of the Esophagogastric Junction Who Underwent Radical Surgery After Neoadjuvant Chemotherapy Combined With Immunotherapy and Achieved pCR in Postoperative Pathology
Sponsor: Liaoning Cancer Hospital & Institute
Summary
This study is to evaluate the efficacy and safety of different postoperative adjuvant regimens in patients with resectable adenocarcinoma of the esophagogastric junction who underwent radical surgery after neoadjuvant chemotherapy combined with immunotherapy and achieved pCR in postoperative pathology
Official title: A Multicenter, Prospective, Real-world Study Comparing the Efficacy and Safety of Different Postoperative Adjuvant Regimens in Patients With Resectable Adenocarcinoma of the Esophagogastric Junction Who Underwent Radical Surgery After Neoadjuvant Chemotherapy Combined With Immunotherapy and Achieved pCR in Postoperative Pathology
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
500
Start Date
2025-09-30
Completion Date
2027-12-31
Last Updated
2025-09-08
Healthy Volunteers
No
Interventions
SOX plus PD-1 inhibitor
SOX or XELOX plus PD-1 inhibitor
PD-1 / PD-L1 monoclonal antibody
PD-1/PD-L1 monoclonal antibody
SOX Chemotherapy
SOX or XELOX
Tegafur-Ugotex or Capecitabine
Tegafur-Ugotex or Capecitabine