Inclusion Criteria:
1. Male or female, 18 to 65 years of age, inclusive, at time of screening.
2. Body mass index between 17-35 kg/m2.
3. Able to read, understand, and provide written, dated informed consent prior to screening. Participants will be deemed likely to comply with study protocol and communicate with study personnel about adverse events and other clinically important information.
4. If female, a status of non-childbearing potential or use of an acceptable form of birth control per the following specific criteria:
1. Non-childbearing potential (e.g., physiologically incapable of becoming pregnant, i.e., permanently sterilized (status post hysterectomy, bilateral tubal ligation), or is post-menopausal with her last menses at least one year prior to screening); or
2. Childbearing potential, and meets the following criteria:
(i) Negative urinary pregnancy test at screening, confirmed by a negative urinary pregnancy test at enrollment prior to receiving study treatment.
(ii) Willing and able to continuously use one of the following methods of birth control during the course of the study, defined as those which result in a low failure rate (i.e., less than 1% per year) when used consistently and correctly: implants, injectable or patch hormonal contraception, oral contraceptives, IUD, double-barrier contraception, sexual abstinence. The form of birth control will be documented at screening and baseline.
Exclusion Criteria:
1. Female of childbearing potential who is not willing to use one of the specified forms of birth control during the study.
2. Female that is pregnant or breastfeeding.
3. Female with a positive pregnancy test at screening or baseline.
4. Current diagnosis of Axis I or II disorders other than Major Depressive Disorders, Dysthymic Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Social Phobia, Specific Phobia, Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorder, Somatization Disorder, Pain Disorder, Sexual and Gender Identity Disorders, Insomnia, Adjustment Disorders, Tic Disorders, and Neurodevelopmental Disorders.
5. Current diagnosis of Axis I disorders other than Dysthymic Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia, Specific Phobia, or Bipolar II Disorder (unless one of these is comorbid and clinically unstable, and/or the focus of the participant's treatment for the past six months or more) History of schizophrenia or schizoaffective disorders, or any history of psychotic symptoms in the current or previous depressive episodes.
6. Any neurological disorder including:
1. Dementia, delirium, amnestic, or any other cognitive disorder
2. Lifetime history of surgical procedures involving the brain or meninges
3. Encephalitis, meningitis, degenerative central nervous system disorder (e.g., Alzheimer's or Parkinson's Disease), epilepsy, developmental delay
4. Any other disease/procedure/accident/intervention associated with significant injury to or malfunction of the central nervous system (CNS),
5. History of significant head trauma resulting in cognitive impairment within the past two years.
7. Any cardiovascular disorder including:
1. Uncontrolled hypertension
2. Congestive heart failure NYHA Criteria \>Stage 2
3. Atrial fibrillation or resting heart rate \<50 or \>105 beats per minute at screening
4. Clinicially significant uncontrolled arrhythmia
5. QTcF (Fridericia-corrected) \>= 450 msec at screening
6. Any cardiovascular disorder that would merit categorization of patient as ASA Class 3 or higher
8. Any pulmonary/respiratory disorder including:
1. Formally diagnosed obstructive sleep apnea (OSA) that is moderate and not treated with a CPAP machine; or formally diagnosed OSA that is severe, regardless of treatment
2. Undiagnosed OSA with a STOPBANG score of 5 or higher
3. History of difficult airway in surgical setting
4. Any pulmonary/respiratory disorder that would merit categorization of patient as ASA Class 3 or higher
9. Clinically significant liver disease, determined by LFTs within the past 6 months
10. Clinically significant kidney disease determined by creatinine / GFR within the past 6 months
11. Symptomatic gastroesophageal reflux disease, hiatal hernia, taking medications causing delayed gastric emptying, or any other gastrointestinal disorder placing the patient at risk for aspiration or that would merit categorization of patient as ASA physical classification status of III or higher
12. Any endocrine disorder including:
1. Uncontrolled diabetes mellitus, type 1 or 2
2. Clinically significant hypothyroidism or hyperthyroidism which has not been stably treated for at least 6 months
3. Any other endocrine disorder that would merit categorization of patient as ASA Class 3 or higher
13. Patients taking any of the following daily medications:
1. Opioids including buprenorphine and methadone
2. Naltrexone or other opioid antagonist
3. Clonidine
14. Any other clinically significant abnormal laboratory result at the time of the screening exam that might affect safety, study participation or confound interpretation of study results
15. Any other clinically significant physical exam abnormality on the screening physical examination that might affect safety, study participation or confound interpretation of study results, including any condition that would merit categorization of patient as ASA Class 3 or higher
16. Participation in any clinical trial with an investigational drug or device that conflicts with this trial, within the past month or concurrent to study participation.
17. Abnormalities noted on anatomy mapping brain MRI as determined by radiologist.
