Clinical Research Directory

Inclusion Criteria: * Aged between 18 and 75 years * No history of major diseases, no previous surgical history, and no history of cardiometabolic diseases (such as hypertension, diabetes mellitus, obesity, etc.) * No use of drugs that may affect gut microbiota or metabolic function (e.g., antibiotics, probiotics, immunosuppressants, etc.); * Voluntarily participate in the study and sign the informed consent form. Exclusion Criteria: * Comorbidities: Complicated with other severe diseases (e.g., immunodeficiency, chronic liver disease, renal insufficiency, malignant tumors, etc.). * Recent infections: Registration records indicate a history of severe infections in the recent period (within 3 months) or currently receiving anti-infective treatment. * Special populations: Pregnant women, lactating women, or women planning to become pregnant. * Poor compliance: Volunteers who are unable to cooperate with the study protocol or follow-up