Clinical Research Directory

Inclusion Criteria: * 22 Healthy Volunteers : healthy Caucasian adults with a BMI \< 25 kg/m\^2 will be recruited with no medical conditions. * 22 Metabolically Impaired Participants: Caucasian adults with a BMI ranging from 28 kg/m\^2 to 40 kg/m\^2 with three components of Metabolic Syndrome, drug-naïve: * Elevated waist circumference (WC): with men having WC \> 102 cm (40 inches) and women having a WC \> 88 cm (35 inches). * High Fasting Plasma Glucose (FPG): a fasting plasma glucose level 110 mg/dL (6.1 mmol/L) * High Fasting Plasma Insulin (FPI): A fasting insulin level ≥25 μU/mL (or \>16.7 pmol/L) * HOMA-IR score of ≥2.5 Exclusion Criteria: * Use of antibiotic in the past 3 months or currently taking them * Past/ Currently following a vegan, strictly organic or vegetarian diet. * History of severe food allergies or intolerances that would render it unsafe for them to consume any of the fruits and vegetables provided. Exclusion will be determined on a case-by-case basis by the investigator. * Inability or unwillingness to collect stools. * Presence of overt type 1 diabetes mellitus (T1DM) and/or type 2 diabetes. * Use of medications for type 2 diabetes: metformin, statin, proton pump inhibitors (PPI), H2 blockers, pioglitazone, active GLP-1 receptor agonists (e.g., exenatide, liraglutide). * Prior or planned bariatric surgery, history of cholecystectomy. * History of cardiovascular disease, having a severe disease of the digestive tract, such as celiac disease, Crohn's disease, active ulcerative colitis. * Surgery scheduled for the trial duration period. * Pregnant or nursing women. * Smoking or illicit drug use. Use of \>5 units of alcohol daily on average. * History of neurological/neurodegenerative disorders. * Participation in another concomitant clinical trial. * Not residing in the Netherlands during study period (Sept-Nov 2025)