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Effect of Different Anesthetic Drugs on Electrocorticography (ECOG).
Sponsor: Children's Cancer Hospital Egypt 57357
Summary
Prospective, double-blind, randomized-controlled study for pediatric cases scheduled for brain tumor excision with the aid of electrocorticography (ECOG). Intraoperative ECOG has been used in an effort to localize the site of epileptogenicity through the demonstration of Interictal Epileptiform Discharges (IED) persistence, frequency, and distribution. During ECOG, pharmaco-activation may be required in order to activate Interictal Epileptiform Abnormalities (IEAs). Frequency of IEAs will be measured for each drug. The effects of anesthetic agents on intraoperative ECOG, as we assume that fentanyl will be superior to ketamine.
Official title: Effect of Different Anesthetic Drugs on Electrocorticography (ECOG), Randomized Controlled Double-blinded Study
Key Details
Gender
All
Age Range
2 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
88
Start Date
2025-08-18
Completion Date
2027-03
Last Updated
2025-09-10
Healthy Volunteers
No
Conditions
Interventions
Fentanyl (IV)
Fentanyl, Intravenous bolus administration at a dose of 1 microgram per kilogram of body weight administered once before spike stimulation and another time after resection of epileptic foci for spike stimulation.
Ketamine (0.5 mg/kg)
Ketamine, Intravenous bolus administration at a dose of 0.5 milligram per kilogram of body weight administered once before spike stimulation and another time after resection of epileptic foci for spike stimulation.
Locations (2)
Children's Cancer Hospital Egypt 57357
Cairo, Egypt
Children Cancer Hospital 57357
Cairo, Egypt