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Mitigating Neural Hypoexcitability and Weakness During Disuse in Women
Sponsor: Kansas State University
Summary
Clinical trial The goal of this clinical trial is to learn how muscle weakness and atrophy develop during short periods of arm immobilization and whether a type of exercise called cross-education can help reduce these effects in women at midlife. The main questions it aims to answer are: What changes happen in the nervous system that lead to weakness when a wrist is immobilized? Can training the opposite arm help maintain muscle strength, muscle size, and nervous system function in the immobilized arm? Researchers will compare women who have their wrist immobilized with or without opposite-arm resistance training. Participants will: Wear a wrist cast on one arm for 7 days Complete strength training with the opposite arm or no training, depending on their group Attend study visits for strength and nervous system testing Have non-invasive tests (like magnetic brain stimulation, muscle recordings, and muscle imaging) to measure how the nervous system and muscle responds
Key Details
Gender
FEMALE
Age Range
40 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-04-01
Completion Date
2027-01-31
Last Updated
2026-03-03
Healthy Volunteers
Yes
Conditions
Interventions
Wrist immobilization
The wrist immobilization will use a medical device (wrist cast) to immobilize the left, non-dominant wrist for 7 days.
Resistance training
The cross-education intervention will consist of resistance training on the dominant hand.
Resistance training rehabilitation
The resistance training rehabilitation will occur for the non-dominant hand following the immobilization phase for all participants.
Locations (1)
Neuromuscular Physiology Laboratory
Manhattan, Kansas, United States