Clinical Research Directory

Inclusion Criteria: * Subjects must understand the nature of the study and must provide signed and dated written informed consent prior to conducting any study-related procedures * Willing and able to comply with all protocol procedures * subjects confirmed the daily (and recent) intake od direct anticoagulants in strandard dosing. * no other antitrombotic drug therapy (e.g. acetylsalicyl acid, clopidogrel, ticagralol, low molecular weight heparin or second direct anticoagulant) is taken. Exclusion Criteria: * Any clinically significant medical or psychiatric condition or medical history that, in the opinion of the investigator, would interfere with the subject's ability to participate in the study or increase the risk of participation for that subject * other antitrombotic drug therapy (e.g. acetylsalicyl acid, clopidogrel, ticagralol, low molecular weight heparin or second direct anticoagulant) is recently taken.