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Multidomain Bedside Assessment of Short-Term Mortality and Readmission in Hospitalized Patients With Metastatic Cancer
Sponsor: Ankara Etlik City Hospital
Summary
This prospective observational study evaluated whether simple bedside assessments performed during an unplanned hospitalization were associated with short-term outcomes in adults with metastatic solid cancer. The assessments included handgrip strength, blood-based cachexia and inflammatory-metabolic indices, body composition measured by bioelectrical impedance analysis, and patient-reported and nutritional measures. The primary outcome was death from any cause within 30 days of the index hospital admission. Additional outcomes were death from any cause within 90 days and the first unplanned hospital readmission within 30 days after live discharge. The study aimed to determine whether different bedside domains were associated with mortality and readmission and whether these associations differed across outcomes. Participants received usual clinical care, and no treatment was assigned by the study.
Official title: Multidomain Bedside Assessment of Short-Term Mortality and Readmission Following Unplanned Hospitalization in Patients With Metastatic Cancer: The PRO-HAND Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
233
Start Date
2024-12-10
Completion Date
2026-01-13
Last Updated
2026-10-09
Healthy Volunteers
No
Interventions
Handgrip Strength Assessment
Handgrip strength was measured within the first 48 hours of the index hospitalization using a calibrated hydraulic hand dynamometer. Measurements were performed on the dominant hand with the patient seated, the elbow flexed at 90 degrees, and the wrist in a neutral position. Three measurements were obtained at 60-second intervals, and the highest value was retained for analysis. Measurement was deferred when acute injury or recent surgery involved the dominant upper extremity.
Locations (1)
Etlik City Hospital, Medical Oncology Department
Ankara, Yenimahalle, Turkey (Türkiye)