Clinical Research Directory

Inclusion Criteria: 1. Children 5-18 years of age 2. Receiving CAPD or CCPD for at least the preceding 4 weeks, and not likely to change from CAPD to CCPD during the study period 3. 24-hour mean arterial pressure (MAP; measured by ambulatory blood pressure monitoring (ABPM) above the 95th percentile for age, sex, and height 4. 24-hour urine output less than 200ml/day Exclusion Criteria: 1. Children under 5 years of age (as younger children are more prone to hyponatremia) 2. Children with systolic BP \< 50th centile for age, sex, and height in the preceding 4 weeks) 3. Children who are polyuric or those prone to hypotension (defined as \> 2 episodes of systolic BP \< 5th centile in the 4 weeks preceding the study) 4. Known allergy to starch 5. Pregnant women 6. Patients with maltose or isomaltose intolerance, glycogen storage disease, pre-existing severe lactic acidosis, uncorrectable mechanical defects that prevent effective PD or increase the risk of infection and documented loss of peritoneal function or extensive adhesions that compromise peritoneal function