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Transfusion Exchanges and Cognition in Sickle Cell Disease
Sponsor: Centre Hospitalier St Anne
Summary
DREPA-COG is an observational study evaluating the effect of exchange transfusions on cognitive function in adults with severe sickle cell disease (SS or Sβ0). Information processing speed is assessed at three time points during the transfusion cycle using the Symbol Digit Modalities Test (SDMT) and additional validated neuropsychological measures. This minimal-risk, fully remote study aims to identify processing speed as a reproducible marker for clinical monitoring and future therapeutic trials.
Official title: Effect of Exchange Transfusions on Cognitive Efficiency in Patients With Sickle Cell Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
85
Start Date
2025-12-03
Completion Date
2027-11-02
Last Updated
2025-09-11
Healthy Volunteers
No
Locations (6)
Assistance Publique - Hôpitaux de Paris Hôpital Avicenne
Bobigny, Île-de-France Region, France
Hôpital Henri Mondor
Créteil, Île-de-France Region, France
Hôpital Kremlin-Bicêtre
Le Kremlin-Bicêtre, Île-de-France Region, France
GHU Paris Psychiatrie et Neurosciences - Hôpital Sainte-Anne
Paris, Île-de-France Region, France
Assistance Publique - Hôpitaux de Paris Hôpital Necker
Paris, Île-de-France Region, France
Centre Hospitalier Saint-Denis
Saint-Denis, Île-de-France Region, France