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Is There a Relationship Between Uric Acid Level and Liver Fibrosis in Obese Patients
Sponsor: Assiut University
Summary
1. Identifying the association between hyperuricemia and NAFLD can lead to early detection and prevention of liver fibrosis in adult obese patients. 2. Understanding the relationship between hyperuricemia and NAFLD can inform targeted therapy, such as urate-lowering treatment, to potentially slow disease progression. 3 - To examine the relationship between serum uric acid levels and liver fibrosis severity\*: Assessing the correlation between serum uric acid levels and the severity of liver fibrosis in adult obese patients with NAFLD. 4- To identify potential mechanisms underlying the association\*: Exploring the potential mechanisms by which hyperuricemia may contribute to the development and progression of NAFLD and liver fibrosis in adult obese patients.
Official title: Association of Hyperuricemia and Non Alcoholic Fatty Liver Disease and Liver Fibrosis Risk in Adult Obese Patients
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
111
Start Date
2025-10-01
Completion Date
2026-12-01
Last Updated
2025-09-15
Healthy Volunteers
Yes
Interventions
*Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .
Lab methods
*Imaging Studies:* 1- Ultrasound 2 - FibroScan
Imaging
Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.
Instrument