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Identifying Genetic Targets in Gynecological Tumors
Sponsor: Azienda USL Reggio Emilia - IRCCS
Summary
This observational study aims to identfy genetic targets involved in the pathogenesis of gynecological tumors, with a focus on high-grade serous ovarian carcinoma. Using a triple approach - in silico, ex vivo and in vitro - the study will investigate the role of gonadotropins and their related signaling pathways in the epithelial ovarian cancers. Gene and protein expression levels will be evaluated through transcriptomic analysis, immunohistochemistry and functional assays on tumor cell lines. The goal is to uncover potential diagnostic or therapeutic targets in gynecological malignancies.
Official title: Identification of Genetic Targets in Gynecological Tumors Via a Triple in Silico Ex-vivo / in Vivo Approach
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
180
Start Date
2021-11-17
Completion Date
2027-11
Last Updated
2025-09-11
Healthy Volunteers
No
Conditions
Interventions
RNA extraction and gene expression
RNA extraction and gene expression
Locations (1)
Azienda USL IRCCS di Reggio Emilia
Reggio Emilia, Italy