Clinical Research Directory

Inclusion Criteria: 1. Patients with active Crohn's disease (CD) who visited the Sixth Affiliated Hospital of Sun Yat-sen University between July 2023 and December 2024; 2. Aged 18-50 years; 3. Complicated with sarcopenia; 4. Willing and able to tolerate oral exclusive enteral nutrition (EEN) therapy; 5. Signed informed consent and able to comply with the study procedures; 6. Colonic or ileocolonic type CD (SES-CD ≥6; if only terminal ileum is involved, SES-CD ≥4). Exclusion Criteria: 1. Short bowel syndrome; 2. High-output jejunal fistula; 3. Severe stress or shock status; 4. Complete mechanical intestinal obstruction, acute gastrointestinal bleeding, or severe intra-abdominal infection; 5. Severe hepatic, renal, or cardiac diseases, or malignant tumors; 6. History of allergy or contraindication to Ensure or HMB; 7. Persistent severe vomiting or intractable diarrhea; 8. Congenital disorders of sugar or amino acid metabolism; 9. Underwent CD-related intestinal surgery or received biologic therapy within the past month, or received immunosuppressive/antibiotic therapy related to CD within 2 weeks prior to enrollment.