Clinical Research Directory

To Assess the Efficacy of Carica Papaya Leaf Extract in Improving Platelet Counts Among Pediatric Patients With Dengue-associated Thrombocytopenia

Sponsor: Ziauddin Hospital

Summary

The goal of this clinical trial is to evaluate whether Carica papaya leaf extract (CPLE) can improve platelet counts in children aged 2 to 12 years diagnosed with dengue fever and thrombocytopenia. The main questions it aims to answer are: Does Carica papaya leaf extract significantly increase platelet counts compared to standard supportive therapy alone? Does the use of Carica papaya leaf extract reduce the need for platelet transfusion or PICU admission? Researchers will compare the group receiving CPLE plus standard therapy to the group receiving standard therapy alone to see if CPLE leads to improved platelet recovery and better clinical outcomes. Participants will: Be randomly assigned to receive either standard care or standard care plus Carica papaya leaf extract syrup (10 mL orally, three times daily for 3 days) Undergo blood testing on Day 1 and Day 3 to assess platelet count, hemoglobin, WBC, and packed cell volume Be monitored for clinical outcomes including need for transfusion and admission to the Pediatric Intensive Care Unit (PICU)

Official title: Effect of Papaya Leaf Extract on Thrombocytopenia in Children With Dengue Fever at a Tertiary Care Center in Karachi

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