Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Comparative Study of Endoscopic Choanal Canalization and Mitomycin C Application vs Endoscopic Crossover Flap Technique
Sponsor: Assiut University
Summary
determine the optimal surgical strategy for achieving 1. long-term outcomes 2. minimizing complications 3. improving outcomes in CCA patients
Key Details
Gender
All
Age Range
0 Months - 72 Months
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-09
Completion Date
2028-09
Last Updated
2025-09-15
Healthy Volunteers
No
Conditions
Interventions
Transnasal Puncture with Mitomycin C application
* Performed under general anesthesia. * Nasal cavities decongested with oxymetazoline. * Atretic plate perforated using serial dilators under direct visualization. * Additional removal of bony/membranous tissue including the posterior nasal septum as possible. * Topical mitomycin C (0.5 mg/mL) applied to the edges of the newly created choana for 2 minutes using cotton pledget in a transparent tube , followed by irrigation with saline. * syndromatic patients and patients requiring less time UGA will be included in this group
Endoscopic Crossover Flap Repair
* Performed under general anesthesia using a 0° 4 mm endoscope. * Elevation of mucosal crossover flaps to cover exposed bone following resection of the atretic plate where one flap is inferiorly based and the other is superiorly based. * Precise removal of the posterior vomer and lateral bony plates as needed using cold steel instruments and possible nasal drill. * Flaps will be repositioned to minimize exposed bone and promote mucosal healing preventing restenosis.