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The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outcomes in Critically Ill Patients
Sponsor: Gelderse Vallei Hospital
Summary
The goal of this clinical trial is to investigate the effect of continuous versus intermittent enteral nutrition on metabolic outcomes in critically ill adult patients. The aim of this study is to: • To assess the effect of a daytime intermittent tube feeding pattern compared to standard continuous tube feeding on glycaemic control, gastrointestinal function, gastrointestinal hormones, markers of sleep quality and circadian rhythm, and lean body mass and body composition. Participants will receive either continuous enteral nutrition for 24 hours a day or intermittent enteral nutrition during the day, consisting of 4 portions each administered over 1 hour between 8 am and 8 pm. The maximum duration of the intervention is 5 days or until participants do not receive exclusive gastric enteral nutrition.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
124
Start Date
2025-09-30
Completion Date
2028-09
Last Updated
2026-03-13
Healthy Volunteers
No
Conditions
Interventions
Intermittent enteral nutrition
Participants will receive intermittent enteral nutrition in four separate portions between 8:00 a.m. and 8:00 p.m. Each portion will be administered over a one-hour period.
Locations (5)
Gelderse Vallei Hospital
Ede, Gelderland, Netherlands
Deventer Ziekenhuis
Deventer, Overijssel, Netherlands
Medisch Spectrum Twente
Enschede, Overijssel, Netherlands
Martini Ziekenhuis
Groningen, Provincie Groningen, Netherlands
Haga Ziekenhuis
The Hague, South Holland, Netherlands