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Advanced Dressings for CVC Infection Prevention in PICU
Sponsor: University of Seville
Summary
Randomised, single-blind clinical trial comparing chlorhexidine gluconate-impregnated transparent dressings versus conventional transparent dressings in the prevention of central venous catheter-related bloodstream infections (CVC-BSI) in paediatric patients admitted to a tertiary hospital PICU. Outcomes include incidence of BRCVC, catheter colonisation, dressing-related skin complications, and number of dressing changes.
Official title: Use of Advanced Fixation Dressings in Reducing Central Venous Catheter-related Bloodstream Infections in a Paediatric Intensive Care Unit
Key Details
Gender
All
Age Range
2 Months - 18 Years
Study Type
INTERVENTIONAL
Enrollment
250
Start Date
2024-05-01
Completion Date
2025-11-15
Last Updated
2025-09-16
Healthy Volunteers
No
Conditions
Interventions
3M™ Tegaderm™ Antimicrobial Transparent Dressing (chlorhexidine gluconate-impregnated)
Individually applied transparent dressing containing chlorhexidine gluconate (0.5-1 mg/cm²) for antimicrobial protection at the central venous catheter insertion site. The dressing maintains site visibility, reduces catheter manipulation frequency, and provides sustained release of chlorhexidine to lower colonisation and bloodstream infection risk.
Conventional transparent polyurethane dressing
Transparent polyurethane dressing without antimicrobial impregnation, applied at the central venous catheter insertion site. This dressing allows site inspection and is widely used in standard paediatric intensive care protocols but provides no antimicrobial activity.
Locations (1)
Hospital Universitario Virgen del Rocío - Hospital Infantil
Seville, Sevilla, Spain