Clinical Research Directory
Browse clinical research sites, groups, and studies.
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
Sponsor: Regeneron Pharmaceuticals
Summary
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillation. The aim of the study is to see how well REGN7508 and REGN9933 work in patients that get medicine for their atrial fibrillation. The bleeding effects of REGN7508 and REGN9933 will be compared to another medicine (apixaban), which is available on the market to treat and prevent formation of blood clots. The study is looking at several other research questions, including: * What side effects may happen from taking REGN7508 or REGN9933 * How well do the study drugs reduce the risk of having a stroke * How much of REGN7508 or REGN9933 is in the blood at different times * Whether the body makes antibodies against REGN7508 or REGN9933 (which could make the drugs less effective or could lead to side effects)
Official title: A Phase 2, Randomized, Multicenter, Open-label, Blinded-endpoint Study to Evaluate the Safety of REGN7508 and REGN9933, Monoclonal Antibodies Against FXI, Versus Apixaban in Participants With Atrial Fibrillation (ROXI-ATLAS)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1200
Start Date
2025-10-20
Completion Date
2027-04-21
Last Updated
2026-04-09
Healthy Volunteers
No
Conditions
Interventions
REGN7508
Administered per the protocol
REGN9933
Administered per the protocol
Apixaban
Administered per the protocol
Locations (41)
SEC Clinical Research
Dothan, Alabama, United States
Eastern Shore Research Institute
Fairhope, Alabama, United States
Mission Cardiovascular Research Institute
Fremont, California, United States
National Institute of California Heart and Vein Specialists
Huntington Beach, California, United States
Profound Research LLC at Southern California Heart Specialists
Pasadena, California, United States
Empire Clinical Research
Pomona, California, United States
Northbay Clinical Research Center
Santa Rosa, California, United States
Cardiology Associates Medical Group
Ventura, California, United States
Interventional Cardiology Medical Group
West Hills, California, United States
Nouvelle Clinical Research LLC
Cutler Bay, Florida, United States
Inpatient Research Clinic LLC
Miami Lakes, Florida, United States
Cardiovascular Center of Sarasota Foundation for Research and Education
Sarasota, Florida, United States
Clinical Site Partners, LLC DBA Flourish Research
Winter Park, Florida, United States
Health Sciences Research Building II
Atlanta, Georgia, United States
NSC Research, Inc
Johns Creek, Georgia, United States
Indiana University
Indianapolis, Indiana, United States
Blue Coast Research Center, LLC
Indianapolis, Indiana, United States
Franciscan Physician Network, Indiana Heart Physicians
Indianapolis, Indiana, United States
Indiana Medical Research
Merrillville, Indiana, United States
Reid Physician Associates
Richmond, Indiana, United States
Monroe Research, LLC
West Monroe, Louisiana, United States
Anderson Medical Research
Ft. Washington, Maryland, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Profound Research LLC
Farmington Hills, Michigan, United States
AA Medical Research Center (MRC)
Flint, Michigan, United States
K&R Research LLC
Marion, Ohio, United States
Advanced Medical Research
Maumee, Ohio, United States
Monument Health Clinical Research
Rapid City, South Dakota, United States
East Coast Institute for Research, Jefferson City
Jefferson City, Tennessee, United States
PharmaTex Research
Amarillo, Texas, United States
Complete Heart Care P.A.
McKinney, Texas, United States
Permian Research Foundation
Odessa, Texas, United States
Tyler Cardiovascular Consultants
Tyler, Texas, United States
Alpine Research TC
Clinton, Utah, United States
GA Research Associates Ltd.
Moncton, New Brunswick, Canada
Health sciences North - Cardiology
Greater Sudbury, Ontario, Canada
Dr James Cha
Oshawa, Ontario, Canada
Heart Health Institute Research Inc. - Cardiology
Scarborough Village, Ontario, Canada
Viacar Recherches Cliniques Inc. - Cardiologie
Longueuil, Quebec, Canada
Diex Recherche Inc.
Sherbrooke, Quebec, Canada
Diex Recherche Trois-rivieres
Trois-Rivières, Quebec, Canada