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RECRUITING
NCT07176273
NA

Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)

Sponsor: The University of Texas Health Science Center at San Antonio

View on ClinicalTrials.gov

Summary

By doing this research project, the investigators hope to learn which strategies work best to help veterans who are not benefiting from their first PTSD treatment or not completing between-session homework assignments regularly that might improve treatment response. The investigators also want to learn how best to match the right type and amount of treatment to each individual veteran. By conducting this research project, they hope to: * See if trying a different treatment strategy for veterans not responding to their first PTSD treatment would be more helpful * See if sending text message prompts between sessions encourages more completion of between-session homework

Official title: Changing the Treatment Course: Clinical Trial of Sequenced Interventions to Optimize Treatment for Veterans With PTSD

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

302

Start Date

2025-12-12

Completion Date

2028-08-14

Last Updated

2025-12-19

Healthy Volunteers

No

Interventions

BEHAVIORAL

Modular Cognitive Processing Therapy

CPT is a first-line treatment for PTSD that includes the following core elements: (a) identification of "stuck points" in thinking that interfere with recovery and (b) using Socratic questioning and a series of Contains the same core elements of CPT, but content is repackaged into modules instead of sessions so that clinicians can select and dose treatment elements according to patient need. Modular CPT contains the same core elements of CPT, but content is repackaged into modules instead of sessions so that clinicians can select and dose treatment elements according to patient need.

BEHAVIORAL

Modular Prolonged Exposure Therapy

PE is a first-line treatment for PTSD that includes the following core elements: (a) in vivo exposure and (b) imaginal exposure to the trauma memory. Modular PE is comprised of the same elements of standard PE, but clinicians select and dose modules (i.e., imaginal exposure, in vivo exposure) based on individual patient need.

BEHAVIORAL

Step Down Treatment

Self-managed treatment will involve receiving a self-help version of the remaining treatment materials and ongoing use of the intervention companion app (CPT Coach or PE Coach).

BEHAVIORAL

Digital Interventions

The prompt will be a text message delivered through VA-approved technology (e.g., PETALS).

BEHAVIORAL

Cognitive Processing Therapy (CPT)

CPT is a first-line treatment for PTSD that includes the following core elements: (a) identification of "stuck points" in thinking that interfere with recovery and (b) using Socratic questioning and a series of progressive worksheets to examine stuck points, develop balanced beliefs, and facilitate the experience of natural emotions.

BEHAVIORAL

Prolonged Exposure (PE)

PE is a first-line treatment for PTSD that includes the following core elements: (a) in vivo exposure and (b) imaginal exposure to the trauma memory. In imaginal exposure, participants repeatedly, systematically approach their trauma memory and related thoughts and feelings. In in vivo exposure, participants repeatedly, systematically approach objectively safe people, places, objects, and situations that they avoid because these stimuli remind them of their trauma.

Locations (4)

Augusta VA

Augusta, Georgia, United States

Ann Arbor VA

Ann Arbor, Michigan, United States

Battle Creek VA

Battle Creek, Michigan, United States

Salt Lake City VA

Salt Lake City, Utah, United States