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Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure
Sponsor: University Hospital Ostrava
Summary
The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support. A parallel objective of the study is to determine whether exogenous in-take of the dietary supplement creatine in patients with subnormal serum creatinine value is associated with a shortened duration of ventilatory support and improved patients outcome.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
492
Start Date
2026-02-02
Completion Date
2028-02-02
Last Updated
2026-02-05
Healthy Volunteers
No
Interventions
Dietary supplement creatine
Dietary supplement creatine. The dosage of creatine will be as follows: for the first 7 days after enrolment, the daily dose will be 2x5g. From days 8 to 21, the daily dose will be 1x5g. The substance will be administered orally or through a nasogastric tube.
Dietary supplement - placebo
Dietary supplement polydextrose as a placebo. The dosage of placebo will be as follows: for the first 7 days after enrolment, the daily dose will be 2x5g. From days 8 to 21, the daily dose will be 1x5g. The substance will be administered orally or through a nasogastric tube.
No intervention
Patients in Group 1 will serve as controls and will receive no intervention, only standard care.
Locations (2)
Chronicare Mund s.r.o.
Brno, Czechia
Chronicare s.r.o.
Milovice, Czechia