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Sling-Fiber Preservation POEM vs. Conventional POEM for Reducing Post-POEM GERD
Sponsor: University of California, Irvine
Summary
Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.
Official title: Sling-Fiber Preservation POEM vs. Conventional POEM for Reducing Post-POEM GERD: A Randomized Control Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2025-12-01
Completion Date
2028-01-01
Last Updated
2025-10-22
Healthy Volunteers
No
Interventions
Conventional POEM
Standard posterior POEM with full-thickness myotomy, including both circular and gastric sling muscle fibers.
Sling Fiber-Preserving POEM
Posterior POEM with selective preservation of gastric sling fibers by limiting myotomy to the right of the second penetrating vessel.
Locations (1)
University of California, Irvine - UCI Medical Center
Orange, California, United States