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Efficacy and Safety of 14-Day Vonoprazan-Based Dual Therapy Versus Quadruple Therapy for Helicobacter Pylori Eradication: A Multicentre, Non-Inferiority Randomized Controlled Trial
Sponsor: Yanqing Li
Summary
This study is a multicentre, non-inferiority randomized controlled trial to compare the efficacy and safety of 14-day vonoprazan-based dual therapy with versus quadruple therapy for the eradication of Helicobacter pylori. The primary outcome is eradication rate, and the secondary outcome includes the incidence of adverse events and compliance.
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
372
Start Date
2025-09-09
Completion Date
2026-12-31
Last Updated
2026-03-10
Healthy Volunteers
No
Conditions
Interventions
14-day vonoprazan-amoxicillin dual therapy
vonoprazan 20mg bid + amoxicillin 1000mg bid
14-day vonoprazan-amoxicillin-levofloxacin-bismuth quadruple therapy
vonoprazan 20mg bid + amoxicillin 1000mg bid + levofloxacin 500mg qd + bismuth 220mg bid
14-day vonoprazan-amoxicillin-clarithromycin-bismuth quadruple therapy
vonoprazan 20mg bid + amoxicillin 1000mg bid + clarithromycin 500mg bid + bismuth 220mg bid
Locations (2)
Qilu Hospital of Shandong University
Jinan, Shandong, China
Qilu Hospital of Shandong University
Jinan, China