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Menstrual Cycle TMS Plasticity Pilot
Sponsor: University of Pennsylvania
Summary
Aim 1: Assess how menstrual cycle phase affects motor cortex plasticity in females. Aim 2: Compare motor cortex plasticity between males and females across the same time points, identifying potential sex differences in TMS response. Aim 3: Examine associations between serum hormone levels and TMS-induced plasticity within and between sexes.
Official title: Pilot Study on Menstrual Cycle-Related Hormonal Effects on Motor Cortex Plasticity Assessed by TMS in Healthy Young Adults
Key Details
Gender
All
Age Range
20 Years - 40 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2025-12-15
Completion Date
2028-10-31
Last Updated
2026-01-09
Healthy Volunteers
Yes
Conditions
Interventions
transcranial magnetic stimulation
Subjects will receive a series of 60 10s trains that will be presented over the course of the \~3.5 min session. Each train will consist of 2 s of stimulation with an 8 s ITI. During the 2 s of stimulation, 10, 50 Hz bursts will be repeated at intervals of 200 ms (5 Hz). iTBS will be administered at 100% of the motor threshold (MT).
Locations (1)
University of Pennsylvania
Philadelphia, Pennsylvania, United States