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Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
Sponsor: University General Hospital of Patras
Summary
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus surgery (FESS) performed under controlled hypotension. Patients are randomly assigned to receive either total intravenous anesthesia with propofol-remifentanil, propofol-remifentanil with adjunct ketamine and magnesium, sevoflurane-remifentanil, or sevoflurane-remifentanil with adjunct ketamine and magnesium. Primary outcomes include serum biomarkers of neuronal injury (S100B and neuron-specific enolase, NSE) measured perioperatively, as well as surgical field visibility and intraoperative bleeding scores. Secondary outcomes include recovery profile and postoperative pain.
Official title: FUNCTIONAL ENDOSCOPIC NASAL AND SINUS SURGERY AND ANESTHESIA: Study of Hemodynamic Parameters During General Anesthesia Compared to the Surgical Field, as Well as Assessment of Cerebral Ischemia Intraoperatively by Measurement of S100B Protein and Specific Neuronal Enolase (NSE).
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2025-09-11
Completion Date
2026-03-20
Last Updated
2025-09-18
Healthy Volunteers
No
Conditions
Interventions
Propofol / Remifentanil
Maintenance of general anesthesia with propofol and remifentanil; no ketamine or magnesium administered.
Ketamine + Magnesium sulfate (drug combination)
Continuous intraoperative infusion per protocol.
Sevoflurane and Remifentanil
Continuous intraoperative infusion per protocol.
Locations (1)
University General Hospital of Patras
Pátrai, Achaia, Greece