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NOT YET RECRUITING
NCT07183293
NA

A Study on Peginterferon Alfa-2b Combined With NAs in Compensated HBV Cirrhosis

Sponsor: Xiamen Humanity Hospital

View on ClinicalTrials.gov

Summary

This study is a multicenter, randomized, prospective trial designed to evaluate the efficacy and safety of pegylated interferon α-2b (Peg-IFN-α2b) combined with nucleos(t)ide analogues (NAs) versus NAs monotherapy in patients with compensated hepatitis B cirrhosis. A total of 30 patients with compensated HBV-related cirrhosis will be enrolled and randomized in a 2:1 ratio to either Experimental Group 1 (n=20) or Experimental Group 2 (n=10). The treatment regimens consist of Peg-IFN-α2b combined with NAs (ETV/TAF/TMF/TDF) or NAs (ETV/TAF/TMF/TDF) monotherapy.

Official title: A Multicenter, Randomized, Prospective Study on the Efficacy and Safety of Peginterferon Alfa-2b Combined With Nucleos(t)Ide Analogues in Patients With Compensated HBV-Related Liver Cirrhosis

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2025-10

Completion Date

2031-09

Last Updated

2025-09-19

Healthy Volunteers

No

Interventions

DRUG

Peginterferon alfa-2b combined with NAs

Subcutaneous injection therapy,Treatment will continue for 48 weeks, with follow-up assessments conducted every 12 weeks. The dosage will be adjusted based on the patient's disease status.

DRUG

NAs

Treatment will continue for 48 weeks, with follow-up assessments conducted every 12 weeks. The dosage will be adjusted based on the patient's disease status.

Locations (2)

Xiamen Hospital of Traditional Chinese Medicine

Xiamen, China

Zhongshan Hospital Affiliated to Xiamen University

Xiamen, China