Clinical Research Directory
Browse clinical research sites, groups, and studies.
Metabolic Effects of Short-Chain Fatty Acids in Healthy Individuals
Sponsor: University of Copenhagen
Summary
The primary objective of this study is to investigate the acute physiological and metabolic effects of ingesting the short-chain fatty acids (SCFA)s propionate (three carbon atoms long; C3:0) and butyrate (C4:0) in healthy men and women. This aim will be addressed through a block-randomized cross-over study including two visits with acute intake of propionate and butyrate, respectively. The hypothesis is that plasma ketone body levels will increase during the first three hours after intake of butyrate, but not propionate, in healthy individuals in the overnight fasted state.
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2025-09-10
Completion Date
2030-09-01
Last Updated
2026-03-10
Healthy Volunteers
Yes
Interventions
Propionate followed by Butyrate
The participants will consume Short-chain fatty acid propionate (SCFA-PRO) followed by Short-Chain Fatty Acid Butyrate (SCFA-BUT).
Butyrate followed by Propionate
• The participants will consume Short-chain fatty acid Butyrate (SCFA-BUT) followed by Short-Chain Fatty Acid Propionate (SCFA-PRO).
Propionate followed by Butyrate
• The participants will consume Short-Chain Fatty Acid propionate (SCFA-PRO) followed by Short-Chain Fatty Acid Butyrate (SCFA-BUT).
Butyrate followed by Propionate
The participants will consume Short-Chain Fatty Acid Butyrate (SCFA-BUT) followed by Short-Chain Fatty Acid Propionate (SCFA-PRO).
Locations (1)
University of Copenhagen
Copenhagen, Copenhagen N, Denmark