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EGPSS for Weight Management in an in Vivo Human Model
Sponsor: Liu Yan
Summary
ndoscopic bariatric and metabolic therapies (EBMTs) have introduced more convenient, minimally invasive, and safe approaches to weight management. Mucosal ablation of the gastric fundus has been reported to limit fundic expansion and promote satiety; however, ablation can cause perforation, infection, bleeding, and other complications. To restrain fundic expansion while minimizing surgical trauma and preserving reversibility, an endoscopic gastric purse-string suturing (EGPSS) technique was developed to reduce gastric volume. This procedure may be suitable for short-term weight management. Safety and feasibility were demonstrated in a porcine model. The present study will evaluate the feasibility of EGPSS in participants with obesity and assess histological and physiological outcomes.
Official title: A Novel Endoscopic Gastric Purse-string Suture Device for Weight Management in an in Vivo Human Model
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2024-07-01
Completion Date
2025-12-31
Last Updated
2025-09-22
Healthy Volunteers
No
Conditions
Interventions
endoscopic gastric purse-string suturing
A dual-tail endoloop will be introduced into the stomach with endoscopic forceps, and will be secured to the gastric wall using endoscopic clips. An endoscope hook was used to tighten both tails of the endoloop until all the clips converged.
Locations (1)
The fifth Medical Center of Chinese PLA General Hospital
Beijing, Beijing Municipality, China