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RECRUITING

NCT07188246

PHASE2

Neoadjuvant, SBRT With Intratumoural Pembrolizumab Followed by Neoadjuvant Chemotherapy in Breast Cancer

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

View on ClinicalTrials.gov

Summary

This study will evaluate the immune-priming effects of stereotactic body radiation therapy (SBRT) regimen coupled with two injections of pembrolizumab in high-risk primary breast carcinoma prior to neoadjuvant chemotherapy. Preliminary results from the investigators' local TRIO Trial suggest that SBRT prior to neoadjuvant chemotherapy (NAC) may result in improved response rates due to the combined effect of radiation therapy (RT) and chemotherapy. The investigators aim to augment this effect with the addition of pembrolizumab, a monoclonal antibody that binds to and blocks programmed cell death protein 1 (PD-1).

Official title: A Trial of Neoadjuvant, Hypofractionated Radiation, With Intratumoural Pembrolizumab Followed by Neoadjuvant Chemotherapy, in Stage 3 or High-risk Stage 2 Breast Cancer

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

Start Date

2026-01-19

Completion Date

2029-02

Last Updated

2026-02-11

Healthy Volunteers

Conditions

Breast Cancer Breast Cancer Stage II Breast Cancer Stage III Breast Cancer Invasive Breast Cancer Triple Negative

Interventions

RADIATION

Radiation

Stereotactic body radiation therapy to the breast

DRUG

Pembrolizumab (KEYTRUDA®)

Two injections

Inclusion Criteria: 1. Invasive ductal carcinoma of any subtype (including invasive mammary carcinoma with lobular features), excluding sarcomatous, signet or metaplastic subtypes. 2. Invasive mammary carcinoma of stages IIB - III (excluding inflammatory breast cancer). Stage IIA is eligible for triple negative and HER2+ breast cancers. a. Clinical staging based on AJCC 8th edition. 3. Lesion palpable by treating physician. 4. Plan to be treated with neoadjuvant chemotherapy. 5. Able to tolerate core needle biopsies and pembrolizumab injection. 6. 18 years of age or older. 7. Able to provide informed consent. Exclusion Criteria: 1. Any serious medical comorbidities or other contraindications to radiotherapy, chemotherapy, or surgery (e.g., uncontrolled diabetes, serious heart condition, etc). 2. Prior treatment for current breast cancer. 3. Previous radiation therapy to the same breast. 4. Inflammatory breast carcinoma. 5. Invasive mammary carcinoma with sarcomatous, signet cell or metaplastic subtypes. 6. Recurrent breast cancer. 7. Clinical or radiologic evidence or suspicion of distant metastatic disease (metastatic workup that requires additional imaging to follow-up on suspicious findings will exclude patients). 8. Any collagen vascular disease precluding radiotherapy at the discretion of the treating radiation oncologist (particularly lupus, scleroderma, dermatomyositis, psoriatic arthritis). 9. No prior stem cell transplantation. 10. Any poorly controlled autoimmune conditions. 11. Current use of corticosteroids or immunosuppressants. 12. Any other malignancy at any site (except non-melanomatous skin cancer) \<5 years prior to study enrollment. Synchronous bilateral breast cancers are acceptable. 13. Inability to tolerate core needle biopsies or pembrolizumab injection. 14. Pregnant or lactating. 15. Under 18 years of age. 16. Inability or unwillingness to provide informed consent. 17. Inability or unwillingness to complete study assessments/interventions and follow-up assessments.

Locations (2)

St. Joseph's Health Care London

London, Ontario, Canada