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Prevalence and Clinical Impact of Airway Opening Pressure in Post-Cardiac Surgery Patients
Sponsor: Laval University
Summary
Airway opening pressure is a key parameter in assessing respiratory mechanics. Current practice primarily relies on indirect assessments of lung mechanics, but growing evidence suggests that direct airway opening pressure measurement could enhance individualized ventilatory strategies. Significant airway opening pressure suggests incomplete alveolar recruitment at end-expiration, which may contribute to ventilation-perfusion mismatch, increased respiratory effort, and postoperative pulmonary complications such as atelectasis and impaired gas exchange. Determining the prevalence and clinical relevance of significant airway opening pressure in post-cardiac surgery patients could contribute to more personalized respiratory strategies and improve postoperative care.
Official title: Prevalence and Clinical Impact of Airway Opening Pressure in Post-Cardiac Surgery Patients: A Prospective Observational Study
Key Details
Gender
All
Age Range
18 Months - Any
Study Type
INTERVENTIONAL
Enrollment
196
Start Date
2025-06-27
Completion Date
2027-06
Last Updated
2025-09-23
Healthy Volunteers
No
Interventions
Airway opening pressure
Airway opening pressure will be measured within one hour of intensive care unit admission (using a standardized low-flow insufflation maneuver flow 5-6 LPM). The inflection point on the pressure-time or pressure-volume waveform- depending on ventilator model-will define the airway opening pressure.
Locations (1)
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Québec, Quebec, Canada