Clinical Research Directory

Inclusion Criteria: 1. men or women ≥ 18 years of age and ≤ 65 years of age; 2. patients with essential hypertension who are not receiving drug therapy or are receiving stable monotherapy (stable therapy: no change in antihypertensive drugs and doses within 30 days before screening); 3. AOBP mean sitting SBP ≥ 140 and \< 180 mmHg (at least 5 minutes rest before measurement, 3 measurements averaged over at least 1 minute apart) and mean SBP ≥ 130 and ≤ 160 mmHg at 24 hours ABPM; Exclusion Criteria: 1. secondary hypertension: kidney disease, endocrine disease, cardiovascular disease and moderate to severe obstructive sleep apnea without CPAP treatment; 2. Grade 3 hypertension (severe): mean AOBP sitting SBP ≥ 180 mmHg, and/or DBP ≥ 110 mmHg; mean ABPM SBP \> 160 mmHg, and/or mean DBP ≥ 100 mmHg; 3. Patients with a history of hypertensive emergencies, or hypertensive sub-emergencies who have severe hypertension with headache, chest tightness, irritability, and epistaxis; 4. high risk of bleeding or abnormal relevant indicators; 5. long-term use of anticoagulants or antiplatelet drugs, including aspirin at any dose, due to treatment; 6. currently using, or within 30 days before dosing or expected to use any drug or other component known to affect blood pressure during the study; 7. Type 2 diabetes with substandard blood glucose control: fasting blood glucose \> 7.8 mmol/L, or 2-hour postprandial blood glucose/random blood glucose \> 10.0 mmol/L, or HbA1c \> 7%; 8. any cardiovascular event within 6 months prior to screening 9. unstable heart disease, such as uncontrolled symptomatic arrhythmia, atrial fibrillation, heart failure NYHA ≥ III, severe left ventricular hypertrophy, or a history of valvular heart disease; 10. 12-lead ECG showed significant abnormal heart rate, arrhythmia or myocardial ischemia; 11. echocardiography revealed heart failure:LVEF\< 50%; abnormal ventricular diastolic function