Clinical Research Directory

Inclusion Criteria: * MS patients with relapsing-remitting MS (RRMS), secondary-progressive MS (SPMS) or primary progressive MS (PPMS) according to the revised McDonald's criteria (Thompson et al. 2017). Age between 18 and 75 years. Written informed consent signed by the subject must be obtained prior to study start Patient must complain about MS related impaired manual dexterity negatively affecting ADL and/or QoL. Patients must have a pathological 9-Hole-Peg-Test (9HPT) as defined by Oxford Grice et al. 2003. Patients must have Arm function in multiple sclerosis questionnaire (AMSQ) score \>41 Exclusion Criteria: * A relapse that started within 60 days prior to screening. Rapidly progressive disease. Any disease/condition that impaired manual dexterity besides MS Any disease other than MS that could possibly explain the patient's signs and symptoms Medical or psychiatric conditions that compromise the ability to comply with the protocol, or to complete the study A history of drug abuse in the 12 months prior to screening