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NOPE37: Angiogenic Factors for Managing Term Preeclampsia
Sponsor: Hospital Universitari Vall d'Hebron Research Institute
Summary
This study tests the hypothesis that, in women with preeclampsia without severe features, delivery management based on sFlt-1/PlGF would reduce the rate of induction of labor without worsening the rate of progression to preeclampsia with severe features and other maternal complications.
Official title: Angiogenic Markers for Confirming Term Preeclampsia (noPE-37 Trial): An Open-Label, Randomized Controlled Trial
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
750
Start Date
2025-12-04
Completion Date
2028-04
Last Updated
2025-12-11
Healthy Volunteers
No
Conditions
Interventions
Intervention arm: expectant management if sFlt-1/PlGF<38
If the angiogenic factors are normal (sFlt-1/PlGF \<38), expectant management will be followed until 39 weeks, instead of delivery at ≥37 weeks of gestation as in standard care for preeclampsia without severe features.
Standard care: elective delivery at 37 weeks of gestation
In the control arm, standard care for preeclampsia without severe features will be followed: elective delivery at ≥37 weeks of gestation.
Locations (23)
Hospital Universitari Dexeus
Barcelona, BARCELONA, Spain
Hospital Universitario de A Coruña
A Coruña, Spain
Hospital General Universitari Dr. Balmis
Alicante, Spain
Vall d'Hebron Hospital Campus
Barcelona, Spain
Hospital Universitario de Cabueñes
Cabueñes, Spain
Hospital Universitario Puerta del Mar
Cadiz, Spain
Hospital General Universitario de Elche
Elche, Spain
Hospital Universitario de Getafe
Getafe, Spain
Hospital Universitari de Girona Doctor Josep Trueta
Girona, Spain
Hospital Universitario San Cecilio
Granada, Spain
Hospital Universitario de Jerez
Jerez de la Frontera, Spain
Hospital Materno Infantil de Gran Canaria
Las Palmas de Gran Canaria, Spain
Hospital Universitari Arnau de Vilanova
Lleida, Spain
Hospital universitario 12 de Octubre
Madrid, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
Murcia, Spain
Hospital Universitari Son Espases
Palma de Mallorca, Spain
Hospital Universitario Virgen de Valme
Seville, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Hospital Universitari de Tarragona Joan XXIII
Tarragona, Spain
Consorci Sanitari de Terrassa
Terrassa, Spain
Hospital Universitari MútuaTerrassa
Terrassa, Spain
Hospital Universitario de Torrejón
Torrejón, Spain
Hospital Universitario Lozano Blesa
Zaragoza, Spain