Clinical Research Directory

Inclusion Criteria: 1. At least 18 years of age 2. Diagnosis of HIV 3. Documentation of at least two historical HIV-1 RNA viral load measurements \<500 copies/mL while on ART obtained by standard assay. 4. No known non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance mutations. 5. Currently on a stable regimen including an integrase strand transfer inhibitor (INSTI) and two nucleoside reverse transcriptase inhibitors (NRTI). Receiving the current regimen for at least 90 days prior to study entry with no intention to change for the duration of the study. Exclusion Criteria: 1. Untreated depression, defined as a Patient health questionnaire 9 (PHQ-9) score \> 15 at time of enrollment 2. Known prior NNRTI resistance, or INSTI resistance. 3. Cytochrome 450 polymorphism resulting in rapid or delayed metabolism of Efavirenz 4. Not currently on a PI based regimen. 5. Does not have an immunocompromising medical condition. (ie malignancies particularly leukemia, lymphoma, use of immunosuppressive or antineoplastic drugs or X-ray treatment). 6. Chronic, acute, or recurrent infections that are current and serious, in the opinion of the site investigator. 7. Breastfeeding patients as well as those whom are pregnant or plan to become pregnant during period of the study. 8. Those with active Hepatitis C or Hepatitis B.