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ACTIVE NOT RECRUITING
NCT07196449
PHASE1

Drug-Drug Interaction of Rifampicin and Cyclosporine on Methotrexate Pharmacokinetics in Healthy Subjects

Sponsor: Seoul National University Bundang Hospital

View on ClinicalTrials.gov

Summary

This study will evaluate how methotrexate is processed in the body when given with low doses of rifampicin or cyclosporine. These drugs may affect how methotrexate is absorbed and cleared, which could change its safety and effectiveness. Healthy volunteers will receive methotrexate with either rifampicin or cyclosporine, and blood samples will be collected to measure drug levels. The findings may help identify possible drug interactions and improve the safe use of methotrexate.

Official title: A Drug-drug Interaction Study to Evaluate the Effect of Rifampicin and Cyclosporine on the Pharmacokinetics of Methotrexate in Healthy Subjects

Key Details

Gender

MALE

Age Range

19 Years - 45 Years

Study Type

INTERVENTIONAL

Enrollment

12

Start Date

2025-05-14

Completion Date

2026-04-14

Last Updated

2025-09-29

Healthy Volunteers

Yes

Interventions

DRUG

Methotrexate

Methotrexate Tab. 2.5 mg (Korea United Pharm)

DRUG

Rifampicin

Rifampin Cap. 150 mg (Yuhan Corporation)

DRUG

Cyclosporine

Cypol-N Cap. 100 mg (Chong Kun Dang)

Locations (1)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea