Clinical Research Directory
Browse clinical research sites, groups, and studies.
Pistacia Lentiscus Oil Nasal Drops for Preventing Recurrence of Chronic Rhinosinusitis
Sponsor: Liaquat University of Medical & Health Sciences
Summary
This retrospective, observational, case-control clinical study evaluated the safety and efficacy of nasal drops containing Pistacia lentiscus oil in preventing recurrence of chronic rhinosinusitis during long-term therapy. Adult patients with chronic rhinosinusitis who received isotonic saline wash plus Pistacia lentiscus oil drops were retrospectively compared with patients who received isotonic saline wash alone, with a total treatment duration of 12 months. The primary outcome was change in Sino-Nasal Outcome Test-22 (SNOT-22) scores, while secondary outcomes included ciliary motility, nasal secretion, biofilm presence, cytological changes, adverse events, and safety/tolerability.
Official title: The Role of Pistacia Lentiscus Oil in the Prevention of Chronic Rhinosinusitis Recurrence During Long-Term Therapy: A Retrospective Observational Case-Control Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2023-04-04
Completion Date
2025-03-30
Last Updated
2026-05-14
Healthy Volunteers
No
Interventions
Pistacia lentiscus Oil Nasal Drops (Bactorinol®)
Bactorinol® nasal drops (medical device containing ultra-fractioned and winterized Pistacia lentiscus oil). Participants received isotonic saline nasal wash plus 5 drops per nostril twice daily for 30 days, followed by 5 drops per nostril twice daily for 15 days per month for the subsequent 11 months.
Isotonic Saline Nasal Wash
Participants received isotonic saline nasal wash alone according to the same administration schedule used in the comparison group.
Locations (1)
Ent Clinic ASST Settelaghi, University of Insubriae
Varese, Italy