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NCT07199101

Multicenter Pediatric Low-Dose CT Protocol: Development and Clinical Verification

Sponsor: Beijing Children's Hospital

View on ClinicalTrials.gov

Summary

Children are sensitive to ionizing radiation, and there are significant regional variations in current pediatric CT radiation doses. Although there are studies on low-dose CT targeting single lesions, these studies require clear clinical indications and support from advanced equipment, making widespread promotion difficult. The establishment of low-dose CT protocols is mostly experience-based; when radiologists lack confidence in image quality, the credibility of diagnostic reports is compromised. Therefore, the development of low-dose protocols must meet the diagnostic confidence of most radiologists, enable clear visualization of key anatomical structures in clinical practice, and satisfy the requirements for disease diagnosis. The purpose of this study is to establish a pediatric low-dose CT scanning protocol using Low-dose Simulation of CT (LDS) technology, and conduct a multicenter randomized controlled trial (RCT) in clinical settings to verify the clinical feasibility of this low-dose CT scanning protocol.

Official title: Development of a Multicenter Low-Dose CT Protocol for Children Based on Low-Dose Simulation Technology and Verification by Clinical Randomized Controlled Trial

Key Details

Gender

All

Age Range

0 Years - 18 Years

Study Type

INTERVENTIONAL

Enrollment

2650

Start Date

2026-01-01

Completion Date

2027-12-31

Last Updated

2025-09-30

Healthy Volunteers

Conditions

Radiation Dose Reduction

Interventions

RADIATION

Low dose CT

Participants will undergo a low dose CT adopting the pediatric low-dose CT protocol established based on low dose simulation technique.