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Duodenal Polyposis Classification in FAP
Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Summary
Duodenal cancer is the leading cause of cancer-related mortality in patients with familial adenomatous polyposis (FAP), yet the current Spigelman staging system provides limited predictive accuracy for advanced neoplasia. The DRACO study (Duodenal Risk Assessment in adenomatous polyposis Coli -Oncogene) is a multicenter, STROBE- and CONSORT-compliant cohort study that analyzes upper endoscopies from genetically confirmed FAP patients across independent cohorts to develop, validate, and externally test two multivariable risk models.
Official title: Novel Endoscopic Classification for Duodenal Polyposis in Individuals With Familial Adenomatous Polyposis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2018-02-02
Completion Date
2030-01-15
Last Updated
2025-09-30
Healthy Volunteers
No
Conditions
Interventions
DRACO
A novel endoscopic classification to predict the risk of duodenal and ampullary high-grade dysplasia and cancer from baseline esophagogastroduodenoscopy (EGD)
Locations (2)
IRCCS Ospedale San Raffaele
Milan, MI, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy