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A Study of GR1802 Injection in Patients With Seasonal Allergic Rhinitis.
Sponsor: Genrix (Shanghai) Biopharmaceutical Co., Ltd.
Summary
Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by immunoglobulin E after exposure to allergens in atopic individuals. The typical symptoms of AR are paroxysmal sneezing, watery rhinorrhea, itching, and nasal congestion, which may be accompanied by ocular symptoms, including eye itching, tearing, redness, and burning sensation, which are more common in patients with hay fever allergies.
Official title: A Multicenter Clinical Trial Evaluating the Efficacy, Safety, Pharmacokinetics, and Immunogenicity of GR1802 Injection in Combination With Background Therapy in Patients With Seasonal Allergic Rhinitis.
Key Details
Gender
All
Age Range
12 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
144
Start Date
2025-09-25
Completion Date
2027-07-31
Last Updated
2025-09-30
Healthy Volunteers
No
Conditions
Interventions
GR1802 injection
Recombinant fully human anti-IL4Rα monoclonal antibody drug.
Placebo
Placebo
Locations (1)
Zhongnan Hospital of Wuhan university
Wuhan, Hubei, China