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Omegapres Versus Solifenacin and Mirabegron Combination Therapy in Treatment of Primary MNE
Sponsor: Mansoura University
Summary
The goal of this clinical trial is to compare combination of Solifenacin and MIrabegron in treatment of primary mono-symptomatic nocturnal enuresis in children. It will also learn about the safety of that combination. The main questions it aims to answer are: Does combination of Solifenacin and MIrabegron lower the number of wet nights? What medical problems do participants have when taking combination of Solifenacin and MIrabegron? Researchers will compare the combination to omegapress to see if the combination works better to treat primary mono-symptomatic nocturnal enuresis. Participants will: Take the combination or Omegapress every day for 3 months Visit the clinic once monthly for checkups and tests Keep a diary of their symptoms and the number of wet nights
Official title: A Randomized Controlled Trial Comparing Mirabegron and Solifenacin Combination Therapy Versus Desmopressin Monotherapy in Treatment of Children With Primary Mono-Symptomatic Nocturnal Enuresis
Key Details
Gender
All
Age Range
6 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2024-12-01
Completion Date
2026-02-01
Last Updated
2025-09-30
Healthy Volunteers
No
Conditions
Interventions
Mirabegron (beta3-adrenoceptor agonist), Anticholinergics
Anticholinergic and B3 agonist drugs used for treatment of mono-symptomatic nocturnal enuresis
Desmopressin (DDAVP)
ADH analogue in treatment of mono-symptomatic nocturnal enuresis
Locations (1)
Urology and Nephrology center - Mansoura University
Al Mansurah, Egypt