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Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients
Sponsor: Zealand University Hospital
Summary
The goal of this observational study is to develop and test an artificial intelligence (AI) model that can detect signs of dementia and related conditions from speech recordings. The main question is whether a speech-based AI model can correctly tell apart people with normal memory and thinking from those with cognitive impairment. The study will also explore whether the AI can distinguish dementia from depression, separate different dementia subtypes, and identify which people with Mild Cognitive Impairment (MCI) are likely to develop dementia. Participants will complete short memory and speech tasks while being recorded. The AI model will analyze these recordings to learn patterns linked to different diagnoses. At the end of the study, its accuracy will be tested on new participants.
Official title: Development and Validation of Non-Invasive Danish Language and Speech Biomarkers for Neurodegenerative Disease Classification by Means of Automatic Speech Recognition With Artificial Intelligence (DetectAI)
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
OBSERVATIONAL
Enrollment
340
Start Date
2025-10-01
Completion Date
2028-06
Last Updated
2025-10-07
Healthy Volunteers
Yes
Conditions
Interventions
Mini-mental State Examination
Participants will be recorded during the test in order til allow the AI to learn and analyze speech patterns.
Addenbrooke's Cognitive Examination
Participants will be recorded during the test in order til allow the AI to learn and analyze speech patterns.
Speech task - Picture Description
Participants will be asked to describe the Cookie Theft Picture from the Boston Diagnostic Aphasia Examination. The task will take 2 minutes. Participants will be recorded during the speech task in order to allow the AI to learn and analyze the speech patterns.
Speech task - Story Retellling
Participants will be asked to retell the fairy-tale "Cinderella", based on pictures that summarize the fairy-tale. In case "Cinderella" is not known, participants are asked to tell a story with a start, a middle and an end based on the provided pictures. The task will take 4 minutes. Participants will be recorded during the speech task in order to allow the AI to learn and analyze the speech patterns.
Fluency tasks
Two fluency tasks from the Addenbrooke's Cognitive Examination. First, the participant is asked to name as many animals as possible within 1 minutes. Next the participant is asked to name as many words starting with "S" as possible within 1 minute. Participants will be recorded during the tasks in order to allow the AI to learn and analyze speech patterns.
MRI
For healthy controls an MRI will be conducted to provide comparable imaging and as part of screening to ensure they do not meet exclusion criteria (neuroradiological findings that could affect cognitive functions). For participants in the follow-up or new referral cohorts, imaging will be performed as part of the standard diagnostic battery and results will be obtained from the electronic journal.
blood sampling
Healthy control participants will undergo a standard blood test panel commonly used in dementia diagnostics. The panel includes complete blood counts, inflammatory markers, kidney- and liver function markers, thyroid-stimulating hormone (TSH), vitamine B12 and folate. These tests are performed to exclude underlying medical conditions that could mimic cognitive impairment. For participants in the follow-up or new referral cohorts, blood sampling will be performed as part of the standard diagnostic battery and results will be obtained from the electronic journal.
Depression screening
Performed on healthy controls to rule out depression using either the geriatric depression scale (GDS) for patients \> 65 year of age or the Major Depression Index (MDI) for patiens \<65 year of age. For participants in the follow-up or new referral cohorts, depression screening will be performed as part of the standard diagnostic battery and results will be obtained from the electronic journal.
Somatic- and neurological examination
Healthy controls will undergo a standard somatic and neurological examination to exclude conditions that may affect cognition. This includes basic neurological assessment and clinical evaluation of general health status. For participants in the follow-up or new referral cohorts, a somatic and neurological examination will be performed as part of the standard diagnostic battery and results will be obtained from the electronic journal
Locations (1)
Zealand University Hospital
Roskilde, Region Sjælland, Denmark